Use Warning/Check. Ethinyl estradiol may inhibit the clearance of benzodiazepines that endure oxidation, thus escalating serum concentrations of concomitantly administered benzodiazepines.
amobarbital will minimize the extent or result of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
Prevent or substitute A different drug for these remedies when achievable. Appraise for loss of therapeutic outcome if medication needs to be coadministered.
diazepam will increase the amount or outcome of avapritinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
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Therapy of benzodiazepine overdose requires shielding the airway, fluid resuscitation, and using flumazenil if indicated. click here Flumazenil works by using aggressive antagonism on the benzodiazepine receptor and may promptly reverse coma.
fosphenytoin will minimize the extent or influence of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
diazepam will enhance the degree or impact of tazemetostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
As with all depression medication, there is a tiny but considerable danger of suicidal views or worsening of depression, notably in kids and adolescents.
Lively metabolites: N-desmethyldiazepam and temazepam, which might be both of those further more metabolized to oxazepam; mainly eradicated by glucuronidation
Use Warning/Monitor. Ethinyl estradiol could inhibit the clearance of benzodiazepines that undergo oxidation, thereby rising serum concentrations of concomitantly administered benzodiazepines.
Lonafarnib may well enhance the AUC and peak concentration of CYP2C19 substrates. If coadministration unavoidable, monitor for adverse reactions and decrease the CYP2C19 substrate dose in accordance with its authorized products labeling.
Coadministration of other CNS depressants or Alcoholic beverages intake may possibly potentiate CNS-depressant consequences of diazepam
Monitor Intently (1)lenacapavir will boost the amount or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism.